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Sigachi Industries announced a significant milestone in its research and development pipeline with the successful advancement of a new Cystic Fibrosis (CF) Active Pharmaceutical Ingredients (APIs) combination comprising Vanzacaftor, Tezacaftor, and Deutivacaftor.
The development marks an important step in Sigachi's strategic focus on expanding its presence in complex, high-value specialty APIs, aligned with global demand for advanced therapies in rare and chronic disease segments.
The global cystic fibrosis therapeutics market is estimated to exceed USD 10 billion, driven by growing adoption of next-generation modulator therapies, long-term treatment requirements, and strong pricing resilience. Against this backdrop, Sigachi's entry into CF APIs positions the Company in a structurally strong and innovation-led therapeutic segment with long-term demand visibility.
Based on internal market assessment and strategic evaluation, the Company is actively exploring strategic collaborations with formulation innovators for R&D and future commercial supply of these CF APIs. Subject to successful partnerships and market progression, the Company estimates a revenue potential of approximately Rs 250 crore per annum commencing from Q4 FY2026–27, making this portfolio a meaningful growth driver.
The CF API combination involves advanced chemistry, multi-step synthesis, and specialised reactions, resulting in high technological complexity and significant barriers to entry, thereby limiting competitive intensity and reinforcing Sigachi's capabilities in complex API manufacturing.
Further strengthening long-term visibility, the innovator patent protection for Vanzacaftor extends until 2039, providing sustained collaboration-led commercial opportunity and revenue stability within the cystic fibrosis therapeutic space.
In his new role, Atul will work closely with the Board and leadership team to align human capital strategy with the company's long-term growth objectives. His responsibilities will include strengthening leadership capability, shaping organizational design, aligning talent and capability development with business priorities, and reinforcing governance and people processes. He will play a key role in ensuring cultural coherence and organizational resilience as Sigachi expands across businesses, geographies, and operating models, while fostering a culture of accountability, engagement, and trust.
Sigachi Industries said it has taken all necessary steps to ensure continuity of operations and day-to-day business activities.
In the interim, deputy group CEO Lijo Stephen Chacko will oversee the operations of the company, it added.
A blast and fire at Sigachi Industries plant in Sangareddy on 30 June 2025 killed 46 people, injured several others, and left eight missing. Police booked six company officials. Local media said arrests followed delays in paying Rs 1 crore compensation to victims’ families.
Sigachi Industries manufactures MCC in 60 distinct grades ranging from 15 microns to 250 microns. Sigachi caters its products to industries, including pharmaceutical, food, nutraceutical, and cosmetic sectors.
On a consolidated basis, net profit of Sigachi Industries declined 50.92% to Rs 10.69 crore while net sales declined 11.55% to Rs 110.48 crore in Q2 September 2025 over Q2 September 2024.