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“SBO-154, our first ADC is ready to advance in phase 1 with this IND submission, and this is an important milestone for SPARC as we hope to improve lives of cancer patients globally.” said Anil Raghavan, CEO of SPARC.
SBO-154 is a novel humanized MUC1-SEA-targeted ADC developed by SPARC for the treatment of advanced solid tumors. SBO-154 specifically binds with high affinity to the SEA domain of MUC1, and functions by the release of the antimitotic payload after internalization and cleavage. The released payload inhibits cell division and, thereby contributes to the shrinkage of tumors. SPARC had licensed anti-MUC1 antibody from Biomodifying a startup from the University of Tel Aviv.
The IND application supports the next phase of development of SBO-154 which has completed the required IND-enabling preclinical studies with favorable results. A global phase-1 dose-escalation and expansion study has been planned to evaluate SBO-154 in treatment of solid tumors.
Antibody–drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells.
SBO-154 is a novel humanized MUC1-SEA-targeted ADC developed by SPARC for the treatment of advanced solid tumours. SBO-154 specifically binds with high affinity to the SEA domain of MUC1, and functions by the release of the antimitotic payload after internalization and cleavage.
The released payload inhibits cell division and, thereby contributes to the shrinkage of tumours. SPARC had licensed anti-MUC1 antibody from Biomodifying a startup from the University of Tel Aviv.
Anil Raghavan, CEO of SPARC, said: 'SBO-154, our first ADC is ready to advance in phase-1 with this IND submission, and this is an important milestone for SPARC as we hope to improve lives of cancer patients globally.'
Sun Pharma Advanced Research Company (SPARC) is a pharmaceutical company focused on continuously improving standards of care for patients globally through innovation in therapeutics and delivery.
The scrip had declined 2.63% to end at Rs 148 on the BSE on Friday.
Finolex Industries Ltd, Sun Pharma Advanced Research Company Ltd, Bajaj Finserv Ltd, Finolex Cables Ltd are among the other stocks to see a surge in volumes on BSE today, 24 March 2025.
Rainbow Childrens Medicare Ltd notched up volume of 5.03 lakh shares by 10:48 IST on BSE, a 74.76 fold spurt over two-week average daily volume of 6733 shares. The stock rose 1.59% to Rs.1,322.70. Volumes stood at 8135 shares in the last session.
Finolex Industries Ltd registered volume of 5.35 lakh shares by 10:48 IST on BSE, a 7.07 fold spurt over two-week average daily volume of 75680 shares. The stock rose 11.14% to Rs.193.50. Volumes stood at 72661 shares in the last session.
Sun Pharma Advanced Research Company Ltd recorded volume of 14.8 lakh shares by 10:48 IST on BSE, a 3.61 times surge over two-week average daily volume of 4.09 lakh shares. The stock gained 1.18% to Rs.149.50. Volumes stood at 12.66 lakh shares in the last session.
Bajaj Finserv Ltd saw volume of 1.44 lakh shares by 10:48 IST on BSE, a 3.35 fold spurt over two-week average daily volume of 43121 shares. The stock increased 1.97% to Rs.1,882.00. Volumes stood at 47109 shares in the last session.
Finolex Cables Ltd saw volume of 1.06 lakh shares by 10:48 IST on BSE, a 2.39 fold spurt over two-week average daily volume of 44151 shares. The stock increased 12.08% to Rs.940.15. Volumes stood at 43016 shares in the last session.
Kalpataru Projects International Ltd, Inox Wind Ltd, Data Patterns (India) Ltd, Triveni Turbine Ltd are among the other stocks to see a surge in volumes on NSE today, 07 March 2025.
Sun Pharma Advanced Research Company Ltd saw volume of 210.38 lakh shares by 14:14 IST on NSE, a 10.63 fold spurt over two-week average daily volume of 19.80 lakh shares. The stock increased 9.66% to Rs.138.23. Volumes stood at 12.07 lakh shares in the last session.
Kalpataru Projects International Ltd registered volume of 59.12 lakh shares by 14:14 IST on NSE, a 7.78 fold spurt over two-week average daily volume of 7.60 lakh shares. The stock rose 3.48% to Rs.948.95. Volumes stood at 26 lakh shares in the last session.
Inox Wind Ltd recorded volume of 532.12 lakh shares by 14:14 IST on NSE, a 7.47 times surge over two-week average daily volume of 71.21 lakh shares. The stock gained 11.36% to Rs.170.60. Volumes stood at 45.97 lakh shares in the last session.
Data Patterns (India) Ltd witnessed volume of 82.39 lakh shares by 14:14 IST on NSE, a 7.36 times surge over two-week average daily volume of 11.19 lakh shares. The stock increased 11.39% to Rs.1,583.00. Volumes stood at 5.2 lakh shares in the last session.
Triveni Turbine Ltd clocked volume of 129.41 lakh shares by 14:14 IST on NSE, a 5.98 times surge over two-week average daily volume of 21.65 lakh shares. The stock gained 9.89% to Rs.588.75. Volumes stood at 85.59 lakh shares in the last session.
Data Patterns (India) Ltd, Sun Pharma Advanced Research Company Ltd, Zen Technologies Ltd and Triveni Turbine Ltd are among the other gainers in the BSE's 'A' group today, 07 March 2025.
Inox Wind Ltd spiked 11.95% to Rs 171.4 at 11:47 IST. The stock was the biggest gainer in the BSE's 'A' group. On the BSE, 7.41 lakh shares were traded on the counter so far as against the average daily volumes of 3.96 lakh shares in the past one month.
Data Patterns (India) Ltd soared 10.31% to Rs 1567.5. The stock was the second biggest gainer in 'A' group. On the BSE, 1.58 lakh shares were traded on the counter so far as against the average daily volumes of 49047 shares in the past one month.
Sun Pharma Advanced Research Company Ltd surged 10.19% to Rs 138.9. The stock was the third biggest gainer in 'A' group. On the BSE, 4.68 lakh shares were traded on the counter so far as against the average daily volumes of 1.06 lakh shares in the past one month.
Zen Technologies Ltd rose 10.00% to Rs 1299.55. The stock was the fourth biggest gainer in 'A' group. On the BSE, 1.32 lakh shares were traded on the counter so far as against the average daily volumes of 1.24 lakh shares in the past one month.
Triveni Turbine Ltd exploded 9.70% to Rs 587.15. The stock was the fifth biggest gainer in 'A' group. On the BSE, 2.27 lakh shares were traded on the counter so far as against the average daily volumes of 1 lakh shares in the past one month.